If the Season 15 systems described here work as outlined, your amulet project starts with the drop, not the Cube. Players comparing D4 items should look for an ancestral amulet with at least 900 item power and one Greater Affix that suits their build. Don't chase Critical Strike Damage just because the number looks impressive. A damage over time build wants a different foundation. Pick the multiplier you'll actually use, then check the remaining stats before committing materials. A strong starting item gives every later upgrade a purpose.
Protect the stat you're building around
The proposed protection step deserves attention before anything else. At the Occultist, select the Greater Affix for enchanting, then choose the option that leaves it unchanged. Under the rules described here, that choice would lock the affix against later Cube modifications. That's the difference between improving your amulet and risking its best feature. Don't assume an unchanged enchant automatically provides protection in every version of the game, though. Check the item and crafting interface before proceeding. An expensive project shouldn't rest on an effect you haven't confirmed.
Give each Prism a specific job
Once that protection is established, separate your offensive rolls from your skill rolls. The Aggressive Tuning Prism is intended for offensive outcomes through Focused Reroll, making Vulnerable Damage one possible target. The Adept Tuning Prism serves a different purpose: core stats and skill ranks. In this route, you'd use Add Affix first, then apply the Adept Prism through Focused Reroll to pursue an all skills bonus. Don't bounce between both projects without a plan. Decide which stat matters most, set a material budget, and stop when the result genuinely improves your build.
Save expensive polishing for a keeper
Getting the right affixes matters more than squeezing out their last few points. Once the layout is settled, Affix Value Reroll would adjust the base values while leaving the protected Greater Affix unchanged. That makes maximum Vulnerable Damage and plus two to all skills the next targets. Then comes Tempering and Masterworking at the Blacksmith. Choose a damage bonus your character can use consistently. For this route, repeated Masterworking attempts aim their critical upgrades at the Greater Affix. Resets can consume plenty of resources, so decide beforehand how much another attempt is worth.
Leave the finishing touches until you're satisfied
Socket the amulet at the Jeweler for the intended Soul Splinter or gem, then choose a legendary aspect that supports your actual rotation. Duelist is an example, not an automatic answer for every character. The proposed Transfigure recipe comes afterward, with a Kullean Tuning Prism intended to preserve future modification options while adding a random bonus. Players searching for D4 items buy should apply the same scrutiny to any candidate: useful affixes first, appealing numbers second. Keep room in your budget for adjustments, because a promising bonus still needs to fit the build.